THERAPEUTIC INDICATIONS:
Treatment of painful conditions and inflammation in rheumatic diseases (rheumatoid arthritis, oeteoarthrItls) and musculo-skeletal affections (tondinitis, bursitis, post-traumatic pain); postoperative pain, primary dysmenorrhea.
CONTRAINDICATIONS: Hypersensitivity to the components of the product or to chemically strictly related substances. The product must not be used in the presence of gastrointestinal ulcer, gastritis, dyspepsia° , serious hepatic or renal diseases, serious heart failure, severe hypertension, serious hernatIc impairments. as well as in patients with hemorrhagic diathesis. Cross-sensitivity is possible with acetyl salicy/laeoidaredimphasswir alana4sIlplauti-inflammato drugs The product should not be administered to those patients In whom acetyl salicylic scl - 4410 or other non steroidal antl-inflammatory drugs cause asthmatic symptoms, rhinitis, nasal polyposis, angioedema or urticaria. The use of the product is contraindlcatcd In case of ascertained or presumed pregnancy, during lactation and in children. The dosage forms In effervescent tablets and sachets contain aspartame as sweetener, therefore relevant use is contralndicatcd In case of phenyiketonuria.
OVERDOSAGE : In case of BREXIN overdosage, a supportive and symptomatic therapy is advisable.
POSOLOGY AND METHOD OF ADMINISTRATION:
Tablets and sachets: 1 tablet or 1 effervescent tablet or 1 sachet (20 mg) a day. Suppositories: one 20 mg suppository daily. In elderly patients, for whom posology must be carefully established by the physician, It might be necessary a dose reduction
side effects.
A prolonged administration of doses higher than 30 mg/day enhances the risk of gastrointestinal (hall' a tablet or half an effervescent tablet and to limit the treatment duration. - Tablets : To divide the tablet, put It on a fiat surface with scoring line upwards. By gently pressing with your thumb, the tablet is broken Into two equal parts. - Effervescent tablets: completely dissolve the effervescent tablet in a glass of water.