Codaphen - N
Syrup
Antitussive
Composition :
Each 5 ml contains:
Active
ingredients:
Dextromethorphan
hydrobromide 5 mg
Chlorpheniramine
maleate 1 mg
Inactive
ingredients:
Methylparaben.
Propylparaben. Sodium citrate anhydrous, Sucrose, Sorbitol solution 70 %, Ethyl
alcohol, Propylene glycol. Derenine. Fraise lautier
Indications:
Temporarily relieves cold symptoms
- Cough due to minor
throat and bronchial irritation
- Sneezing
- Runny nose
Dosage &
Administration:
As directed by the
physician or as follows:-
• Repeat dose every 6 hours. as needed
Do not take more than 4 doses in any 24 hour period
- 6 to 11 years. 1
tablespoonful (15 ml) every 6 hours
- Adults & Children 12 years and older: 2 tablespoonfuls
(30 ml) every 6 hours
Pharmacological
Actions:
Dextrornethorphan
hydrobromide is a cough suppressant used for the relief of non-productive
cough: it has a central action on the cough centre In the medulla It is also an
antagonist of N-methyl-D-aspartate (NMDA) receptors. Chlorpheniramine maleate.
an alkylamine denvatwe. is a sedating antihistamine that causes a moderate
degree of sedatiomit also has antimuscarinic activity. It is used for the
symptomatic relief of allergic conditions Including urticana and angioedema.
rhinitis, conjunctivitis and in pruritic skin disorders. It is a common
ingredient of compound preparations for symptomatic treatment of coughs and the
common cold
Pharrnacokinetics:
Dextromethorphan is rapidly absorbed from the
gastrointestinal tract. It is metabolised in the liver and excreted in the
urine as unchanged dextromethorphan and demethylated metabolites including
dextrorphan which has some cough suppressant activity Chforpheniramine maleate
is absorbed relatively slowly from the gastrointestinal tract, peak plasma
concentrations occurring about 25 to 6 hours after oral doses. About 70% of
chlorpheniramine in the circulation is bound to plasma proteins There is wide
interindividual variation in the pharmacokinetics of chlorpheniramine; values
ranging from 2 to 43 hours have been reported for the half-life.
Chtorpheniramine is widely distributed in the body and enters the CNS.
Chlorpheniramine maleate is extensively metabolised. Metabolites include
desmethyl- and didesmethylchlorpheniramme. Unchanged drug and metabolites are
excreted pnmarily in the urine: excretion is dependent on urinary PH and flow
rate. Only trace amounts have been found in the faeces.
Contraindications:
Ask a doctor before
use if you have - Trouble urinating due to an enlarged prostate gland -
Glaucoma - A cough that occurs with too much phlegm (mucus) - A breathing
problem or chronic cough that lasts a' as occurs will! smoking asthma, chronic
bronchitis, Or emphysema - A sodium - restricted diet
Side Effects: When using this product-- Do not use more than
directed - Marked drowsiness may occur -Avoid alcoholic drinks - Alcohol,
sedatives and tranquilizers may increase drowsiness - Be careful when driving a
motor vehicle or operating machinery - Excitability may occur, especially In children
Drug Interactions: Do not use if you are now taking a
prescription monoarnine oxidase inhibitor (MA01) (certain drugs for depression,
psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks
after stopping the MA01 drug. If you do not know if your prescription drug
contains a MA01, ask a doctor or pharmacist before taking thus product. Ask a
doctor or pharmacist before muse if you are taking sedatives or tranquilizers.
Pregnancy & Lactation: If pregnant or breast - feeding, ask a health
professional before use Precautions & Warnings: Do not use for children
under 6 years. It is not recommended for use in diabetic patients It may cause
allergic reactions (possibly delayed) If you have been told by your doctor that
you have an intolerance to some sugars. contact your doctor before taking this
medicinal product Stop use and ask a doctor if cough lasts more than 7 days.
comes back or is accompanied by fever, rash, or persistent headache. These
could be signs of a serious condition
Package & Storage:
Carton box containing
amber glass bottle (Type 111) 01120 ml and an inner pamphlet Store in airtight
containers away from light. Store at a temperature not exceeding 30.0
-
Instructions to patients:
-
Keep out of the reach of children.
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