Indications:
neuropathlea .Trigentinal neuralgia. rheumatic pains .
2.Polyneuriiis, Optic neuritis, Diabetic neuritis, Alcoholic neuritis.
3.NeurItis of pregnancy.
4.Vomiiing of pregnancy.
5.Neuromuscular disorders. Tremors. Cramps.
6Antientia: nutritional inacrocytie anaemia, megaloblastie anaemia of infancy, anaemia of pregnancy. pellagra and following gnIrectolny and in pernicious anaemia
Dosage and administration: VIP(
Infection: - Ube contents of the ampoules I and 2 are mixed and infected Intramuscularly daily 01 as directed by the physician. Tablets:- 1.2 tablets daily or as directed by the physician.
Contraindications:
I•Not used to trial meg:fluidal/Me anaemia of pregnancy.
2-Patients with known sensitivity to any of the components.
Side effects: Parenteral administration of thiamine hydrochloride solutions may cause allergic reactions.
Drug Interaction:
· Colchicine may interfere with n itatitin 112 absorption leading to megaloblastic anaemia.
- Reduced absorption of vitamin It was observed in case of patients receiving 'min.:dont citrate or calcium gluconate with metformln. - Biochemical interactions occur between pyridoxal phosphate and certain drugs as Isoniarid (Increase urinary excretion of ‘111101i0 Penicillamine (prolonged use), cycloscrine and /is dralacine .
- Vitamin 86 enhances peripheral decarbonc)lation of les odopa :Ind reduces its effectiveness thus maul be avoided in patients necking Ins odopa
· the effect of folic acid may he diminished In patients receiving barbiturates, and co- trImosazole.
· Folic acid should not be given to patients using Ando,nns itisants us netts loin. phenobarbitone or primodone since it reduces their blood levels.
-Sulphasalazine can intpair the absorption of folic acid in the gut.
Pregnancy and lactation:
· Ind II-dearly needed in pregnancy.
· Vitamin B complex excreted in breast milk. sin caution should be taken during lactation.' Precautions and warnings: Serious hypersensith By reactions may occur. Package and storage:
vei•r,mr.• Box of 6 double
ampoules.
Box of 2 strips s tablets.
Cade N0.
2.'20D9
Box of 3 double ampoules.
rob.
-Store Inn dry place away from light.
-Store In a temperature below 2.5°C. 6 Amu. 351239
Instructions to patients:
Keep out of reach of children.
Manufactured by The NILE Co. for Pharmaceuticals and Chemical Industries - Cairo - A.R.E. R.C.C. 115668