Cobol
Mecobalamln 500 mcg
Folic acid 200 mcg
Composition:
Each Cobol F film-coated tablet contains:
Mecobalamln 500 mcg
Folic acid 200 mcg
Inactive ingredients: Lactose monohydrate, maize starch,
ethanol 99%, magnesium stearate and hydroxypropyl methylcellulose ES.
Indications:
- Prevention of pregnancy complications such as: early
abortion, low-birth weight, neural tube defects, pre-eclampsia, placental
abruption, and maternal hyperhomocysteinaemia associated with increased risk of
congenital heart disease.
- Treatment and
prevention of folate deficiency state.
- Megaloblastic
macroeytic anaemia.
- Malaise and
fatigue.
- Reduces risk of cardiovascular disorders, as it decreases
homocysteine level in the blood.
- In cases of
inadequate nutrition. e.g. elderly people and vegetarians.
- Osteoporosis and
lumbago.
- Male and female infertility caused by hypovitaminosis B
12.
Dosage and
administration:
Two to three tablets
to be taken daily, or as prescribed by the physician.
Pharmacodynamics:
Cobal F is a combination of meeobalamin and folk acid. Mecobalamin, is a
water-soluble vitamin 1312. Vitamin BI2 occurs in the body mainly as
methylcobalamin (mecobalamin), adenosylcobalamin (cobaniamide) and
hydroxycobalarnin. Mccobalamin, as one of the two active coenzyme forms of
vitamin 1312 (the other being adenosylcobalamin), plays an important role as a
coenzyme of methionine synthetase in the transmethylation of homocysteine to
methionine. Mecobalamin removes the methyl group from methyltetrahydrofolate to
form tetrahydrofolate which participates in purine, pyrimidine, and nucleic
acid synthesis. Folic acid (pteroylglutamic acid), member of the vitamin 13
group, is the parent compound for a large number of derivatives collectively
known as folates. Folic acid stimulates production of red, white blood cells
and platelets in certain mcgaloblastic anaemias.
Pharmacokinetics:
Evidence indicates
that mecobalamin is utilised more efficiently than cyanocobalamin to increase
level of vitamin 812. It is stored in the liver, excreted in the bile, and
undergoes extensive entcrohepatic recycling.
Human urinary excretion of mecobalamin is about one-third that of a
similar dose of cyanocobalamin, indicating greater tissue retention. Folic acid
is rapidly absorbed from the gastrointestinal tract, mainly from the duodenum
and jejunum. Folic acid administered therapeutically enters the portal
circulation largely unchanged. The principal storage site of folate is the
liver; it is also actively concentrated in the CSE Mate metabolites arc
eliminated in the urine and folate in excess of body requirements is excreted
unchanged in the urine. Folate is distributed into breast milk. Folic acid is
removed by haemodialys
Side effects:
Mecobalamin and folic
acid are generally well tolerated and no known toxicity. Gastrointestinal
disturbances such as loss of appetite, nausea, diarrhoea or other symptoms of
gastrointestinal upsets may infrequently appear. Hypersensitivity reactions or
skin rash may rarely occur.
Contraindications:
Hypersensitivity
reactions to mecobalamin, folic acid or any ingredient in the product.
Precautions:
Caution is advised in
patients who may have folate-dcpendent tumours.
Drug Interactions:
No drug interaction
of major clinical significance has been reported with Mecobalamin. However, the
gastrointestinal absorption of vitamin 1312 substances in general may be
decreased by colchicine aminoglycoside, antibiotics, aminosalicylic acid and
its salts, and by excessive alchohol intake lasting than 2 weeks.
Pregnancy and
lactation:
Studies have not been done in humans. In animals,
mecobalamin was not found teratogenic. Mecobalamin is distributed into breast
milk.
Presentation:
Cobol F tablets are
supplied in boxes of 20 tablets each. Store at temperature not exceeding 30°C,
in dry place, away from light.
Keep out of reach of children
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