Ciprofloxacin

Indications:

Ciprofloxacin is indicated for the treatment of:

Lower respiratory tract infections caused by E. cloacae, E. coli. H. influenza. K. pneumonia , P. mirabilis, and Ps aeruginonsa.

• Urinary tract infections, prostitutes and gonococcal  urethritis

• Skin and soft-tissue infections caused by Citrobacter freundll   E. cloacae. E coli K. pneurnoniae, morganella morgail, P mirabilis, P vulgaris. Providencia  stuartil . Ps aerugionsa, Staphylococcus.aureus

 (including methicillin • resistant strains) and S epidermidis.

- Bone (including joints) infections caused by Enterobacter cloacae. Pseudomonas aeruginosa. Serratia  marcescens and Staphylococci. Infectious diarrhea caused by Campylobacter jejuni. Enterotoxaenia E. coli Shigella flexneri  and S. sonnei

CIPROFLOXACIN and RIFAMPIN should profitably be given concurrently for the treatment of complicated Staphylococcal infections in the lungs.

CIPROFLOXACIN is also used for treating and reducing the incidence of infections in neutropenic patients and in reducing meningococcal and typhoid carner states.

 Dosage and administration: Tablets

The presence of food in the stomach may daisy absorption of CIPROFLOXACIN. However. the overall absorption is not affected. therefore C/PROFLOXACIN tablets may be taken with meals or on an empty stomach CIPROFLOXACIN tablets Should be given with a full glass of water.

• The duration of treatment depends upon the severity of infection. Generally. CIPROFLOXACIN should be continued for at least 2 days after the signs and symptoms of infection have disappeared.

 - The usual duration is 7 to 14 days. Bone and Joint infections may require treatment for 4 to 6 weeks or longer.

 • Adults with impaired renal function may require a reduction in dose

Contra-indications:

Allergy to CIPROFLOXACIN Of other quinolones

CURISAFE

Indications:

 CURISAFE is indicated in the treatment of infections caused by Cefadroxil-susceptible strains of Gram-positive Pathogens including .lactamase and non -laclomase Producing Staphylococcl  -hemolytic streptococci.Streplococcus pneumonia," and Streptococcus pyogenes. It Is also effective against several Gram-negative bacteria as follows-. • Infections of the Respiratory Tract, sinusitis  otitis media  tonsillitis pharyngitis  laryngitis bronchitis bronchopneumonia bronchiectasis pulmonary abscess empyema and pleurisy

 infections of the Skin and Soft tissues

infected traumatic and posteperative wounds.

 • Infections of the Urfnery Tract: pyalonephrills, cystitis, urethritis.

• Infections of the Genital Tract In Adults : prostatitis . orchitis, epididymo orehitis, adnexities endometritis and other genital infections

• Miscellaneous Infections: osteomyelitis. septic arthritis, intra-abdominal Infections and dental infections.

DOSAGE AND ADMINISTRATION:

Curisafe is acid stable and may be administered orally regard to meals. administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with Oral Cephalosporin therapy.

 ADULTS: Urinary Tract Infection: for uncomplicated lower urinary tract infection (i.e..cystitis) the usual dosage is 1 or 29 per day in single dose or two equally divided doses. For all other urinary  tract infection the usual dosage is 2 g per day in two equally divided doses. Skin and skin structure infections: for skin and skin structure infections the usual dosage is 1 g per day in a single dose or two equally divided doses. Pharyngitis and Tonsillitis: due to group A beta-hemolytic streptococcal pharyngitis and tone/141s - 1 g per day In or a single dose two equally divided i doses for at least ten days upper and lower respiratory tract Infections: for mild infections the usual dosage is 1 g per day in two equally divided doses. Moderato to saver infections the recommended dosage is 1 g to 29 daily in two equally divided doses. Children: the recommended dosage for children is 25 to 50 mg/kg/day in two equally divided doses (every 12 hours) as indicated. For pharyngitis, tonsillitis and impetigo the recommended daily dosage my be administrated as single dose or in boo equally divided doses (every 12 hours)

Side Effects: CURISAFE is safe and well-tolerated. CURISAFE might cause GI disturbances including nausea, abdominal cramps and diarrhea. Less common side effects include urticaria, skin rash. angioneurotic edema and transient leucopenia.

Pregnancy and Lactation :

 Preparations containing cephaiesporins are used during pregnancy and lactation only if clearly indicated

Combifloxin

Indications:

Combifloxin is indicated in the treatment of a wide range of infections such as:

I-Respiratory Tract infections:

 - Bronchitis - Pneumonia – Emphysema

 2- Ear, Nose and Throat infection:-

  Otitis Media - Sinusitis - Tonsillitis - Pharyngitis

3- Gastro- Intestinal Tract Infections:

 - Enteritis - Typhoid & Paratyphoid fever - Cholecystitis –

 4-titirto genital Tract Infections

 - Cystitis - Pyelonephritis - Prostatitis -Gonorrhea

5- Skin and Soft- Tissue Infections:

-Boils -Abscesses -Carbuncles - Cellulitis -Post-Operative wound infections - Intra abdominal sepsis

6-Bone infections:

-Osteomyelitis -Septic arthritis

7-Other infections:

-Septicaemia -Endocarditis -Peritonitis - Billiary tract infections

Dosage Administration:

 Adults: 250-1000 mg every6-8 hours

Contraindications:

 Patients with known hypersensitivity to penicillin

Side effects:

 As with other penicillin, side effects are usually mild and transient and they are limited to diarrhea, indigestion and skin rashes.

Precautions:

 In patients with sever renal impairment, dose should be reduced

Packing:

 A Box of 8 tablets in a blister

CIPROFAR

Indications

Ciprofar is indicated for treatment of infections caused by ciprofloxacin-susceptible organisms:

 • Urinary tract Infections :

 pyelonephritis, cystitis and urethritis including complicated and uncomplicated conditions.

 • Genital tract infections :

 prostatitis, epididymilis. epididymo-orchitis, salpingibs and Salcingo-oophoritis.

• venereal diseases :

 urethral and cervical gonorrhea. nongonococcal urethritis and chancroio.

• Gastrointestinal tract infections :

infectious diarrhea, enteritis, enter000litis and enteric ( typhoid and paratyphoid ) fevers.

• Biliary tract infections :

 cholecystitis, cholangilis and chcledochitis

Calcium

Dosage:

Adults 1 - 2 sachets daily.

Children 1/2 – 1 sachet daily (-before or-during-meals ).

 Dissolve the content of the sachet in half glass of water to get a palatable effervescent solution & drink immediately

Indications:

 - During childhood, pregnancy & lactation to overcome the increased demand for calcium.

-osteomalacia , rickets, post-menopausal & senile osteoporosis.

- Cases of excessive loss or reduced absorption of calcium such as in prolonged treatment with corticosteroids, in cases of gastrectomy & in hypoparathyroidism.

 - Renal osteodystrophy.

 - Chronic renal failure

Side effects: Minor gastrointestinal disturbance rarely occurs

Contraindications:

 Hypercalcaemia, hypercalciuria , calcium renal calculi